Its good fun so far, although its a little clunky with a mouse and keyboard. I wish they'd stop designing PC games with consoles in mind.
The conversation wheel thing is a bit lacking too, like with the Mass Effect series, you're not entirely sure what your character is going to say based on the options.
VATS not pausing time is a bit annoying for me too, I liked to stop and think for a bit in the previous games although that wasn't very realistic, but then the entire Fallout universe isn't very realistic.
I love how you can customize your power armour now and how its more like a vehicle than a piece of clothing, and having to change its fusion core is a good change IMO. The trouble is that its completely buggered up the canon/lore since it was clearly stated in the previous games that different models of power armour used different underlying mechanisms(servos, hydraulics etc) and used different power sources, but now they all share the same frame and fusions cores.
All that said its an excellent game
